Conformational analysis of the sugar ring in nucleosides and nucleotides. A new description using the concept of pseudorotation.
نویسندگان
چکیده
منابع مشابه
Volumetric and Viscometric Studies of Nucleosides, Nucleotides and Furanose Sugar in Aqueous Medium from 288.15 to 298.15K
Density (r/g cm-3) and viscosity (h/10-2gcm-1s-1=1centipoise,CP) of guanosine monophosphate (GMP) and adenosine triphosphate (ATP) referred to as nucleotide, and 2-deoxy adenosine (DOA) and thymidine (TMD) as nucleoside along with their integral furanose sugar, 2-deoxy ribose (DOR) from 0.0004 to 0.0014mol kg<su...
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Conformational properties of N-aryl-1-azacyclooctan-5- ones with a p-methyl, m-methyl, and p-methoxy group as a substituent have been studied by 1H-NMR, 13C-NMR and IR spectroscopies. Transannular interaction of the two functional groups have been examined from the ring inversion barriers and the carbonyl vibrational frequencies with reference to the corresponding data...
متن کاملCorrelation between glycosyl torsion angle and sugar ring pucker does not always exist.
A survey of the conformational parameters of deoxypyrimidine nucleosides and nucleotides shows that the correlation between glycosyl torsion angle and sugar pucker, which has often been considered to be well-established, does not always exist. This may be of significance when interactions between DNA and other molecules are considered.
متن کاملSynthesis and structural characterization of pyrimidine bi- and tricyclic nucleosides with sugar puckers conformationally locked into the eastern region of the pseudorotational cycle.
Reaction of 5'-O-tosyl TSAO-m(3)T (1) with amines has led to the synthesis of new classes of bi- and tricyclic nucleosides. Full details about the synthesis of these compounds and a plausible mechanism to explain their obtention are reported. In addition, we describe the development of a second, more efficient, and higher yielding synthetic route as a general approach for the synthesis of some ...
متن کاملATTEMPTED SYNTHESIS OF 5' - DEOXY - 5' - PHOSPHONO - ISOCYTIDINE SYNTHESIS OF PHOSPHONIC ACID DERIVATIVES OF ACYCLO - NUCLEOSIDES. PREPARATION OF 1- ?- D- ARABINOFURANOSYL PYRIMIDINES
The synthesis of 5' - deoxynucleoside 5' - phosphonates which contains a 5' - CP bond in place of the 5' -COP bond of the naturally occuring nucleotides is described. The preparation of phosphonate derivatives of acyclo - nucleosides and a simple method for the conversion of 1-? -D-ribofuranosyl pyrimidines to the corresponding 1-? -D-arabinofuranosyl pyrimidines are also explained
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 94 23 شماره
صفحات -
تاریخ انتشار 1972